lich是什么意思,lich中文翻譯,lich怎么讀、發(fā)音、用法及例句
?lich
lich 發(fā)音
英:[l?t?] 美:[l?t?]
英: 美:
lich 中文意思翻譯
n.(Lich)人名;(德)利希
n.尸體(等于lych)
lich 網(wǎng)絡(luò )釋義
n. 尸體(等于lych)n. (Lich)人名;(德)利希
lich 短語(yǔ)詞組
1、lich-gate n. ( ─── 教堂墓地入口處有頂的)停柩門(mén)
lich 相似詞語(yǔ)短語(yǔ)
1、Mich ─── n.米奇
2、dich ─── n.(Dich)人名;(丹)迪克
3、lichi ─── n.荔枝;荔枝樹(shù)(等于litchi)
4、linch ─── n.(Linch)人名;(英)林奇
5、licht ─── n.(蘇格蘭)光;燈(等于light);vt.點(diǎn)燃;使明朗;vi.點(diǎn)著(zhù);發(fā)亮;adj.輕的;輕松的;adv.輕便地;輕輕地;少許;n.(Licht)人名;(英、德、匈、捷)利希特
6、Rich ─── adj.(Rich)(美、英、加)里奇(人名);adj.(rich)富有的;肥沃的;昂貴的
7、laich ─── 低的
8、lech ─── n.肉欲;好色的人;vi.好色;縱欲;adj.好色的;n.(Lech)人名;(瑞典)萊克;(德)萊希;(波、捷)萊赫
9、ich ─── (德)我要;n.(Ich)人名;(越)益
lich 常見(jiàn)例句(雙語(yǔ)使用場(chǎng)景)
1、Lich's Sacrifice Ritual cannot cast on Mechanical Units. ─── 巫妖天生技能犧牲儀式不能對機械單位使用。
2、Years after the destruction of Draenor、the immensely powerful Lich King created a new breed of death knights: malevolent、rune-wielding warriors of the Scourge. ─── 很多年后,無(wú)比強大的巫妖王制造了新一代死亡騎士:那些燃燒軍團中險惡的,揮舞著(zhù)符文的戰士。
3、38 cases of erosive lich planus were treated in random with single-blind control method with MEBO or aureomycin glycerol paste (AGP). ─── 作者用濕潤燒傷膏與金霉素甘油糊劑(AGP)隨機單看對照治療38例糜爛型扁平苔鮮病人。
4、In Wrath of the Lich King, you will be able to pick up a runeblade, don some plate armor, and wreak serious havoc using both melee abilities and offensive magic. ─── 在巫妖王之怒會(huì )加入一個(gè)新職業(yè)而且是第一個(gè)英雄職業(yè),這就是通靈死亡騎士。
5、Knowing he had sealed the fate of the high elves, Arthas departed with the newly resurrected Kel'Thuzad to carry on in service of the Lich King. ─── 在知道自己已經(jīng)封存了高等精靈的命運之后,阿爾薩斯與復活的克爾蘇加德離開(kāi)了被廢棄的城市。
6、10. Years after the destruction of Draenor, the immensely powerful Lich King created a new breed of death knights: malevolent, rune-wielding warriors of the Scourge. ─── 很多年后,無(wú)比強大的巫妖王制造了新一代死亡騎士:那些燃燒軍團中險惡的,揮舞著(zhù)符文的戰士。收藏指正
7、The lich King gived me the true power, I will kill my father ereyonce. ─── 巫妖王給了我真正的力量,我會(huì )次次殺死我的父親。
8、Now released by the Lich King to aid in his crusade against the Sentinel, he cleaves through waves of enemies with his mighty anchor, breaking enemy sieges before they even begin. ─── 因此,它天生就有強大的魔法控制力,可以在施法的時(shí)候恢復它和它盟友的法力。它驕傲并狡猾,非常喜歡囚禁敵人并剝奪他們的智力。
9、Doomguard and Infernal pets will be improved at some point in the future, quite possibly in Wrath of the Lich King. ─── 惡魔守衛和地獄火寵物將在“不遠的將來(lái)”得到增強;最可能的時(shí)候是在《巫妖王之怒》里。
10、Highlord Trion Fordring says: The Lich King must answer for what he has done and must not be allowed to cause further destruction to our world. ─── 大領(lǐng)主提里奧.弗?。何籽醣仨殲樗乃魉鶠楦冻龃鷥r(jià)!而我們也不能再允許他對這世界胡作非為!
11、The skies of Outland darkened as Kil'jaeden himself appeared before Illidan, furious at Illidan's failure to destroy the Lich King. ─── 基爾加丹對伊利丹未能擊敗巫妖王一事大感震怒,他的怒火令外域的天空都為之黯淡。
12、The Lich King watches over us, minions! ─── 巫妖王庇護我們,奴仆們!
13、To a time before the Scourge.Before Arthas and regicide ... before the Lich King. ─── 主教斯基特稱(chēng)那一天為“赤色黎明”。
14、Lich's Mirror shuffles tokens you own into your library, too. ─── 巫妖秘鏡也會(huì )將你擁有的衍生物洗入你的牌庫。
15、5.Raised to serve the Lich King as a Banshee, she desired to become pure substance once more. ─── 在被巫妖王復活成女妖之后,她決定為自己尋找新的軀體。
16、71 A powerful lich has unleashed an undead horde against a dwarf city. ─── 71一個(gè)強大的巫妖釋放了一個(gè)不死部落以對抗一座矮人城市。
17、Death song, death door, death river awaiting! Lich! Scatter frozen blade of air! Clops! ─── 寒冷的凍氣遮蔽了陽(yáng)光,凝結的大氣化為刺骨的利刃,去吧,刻下你的傷痕!
18、h King yells: PUPS OF ORGRIMMAR! HEAR ME, BRASH UPSTARTS OF THE HORDE! TREMBLE, AND KNOW YOUR DOOM, FOR THE LICH KING'S GAZE IS FIXED UPON YOU! ─── 巫妖王的使者喊道:奧格瑞瑪的小子們。聽(tīng)我說(shuō),無(wú)理傲慢的部落!恐懼吧,你們的末日即將來(lái)臨,巫妖王在看著(zhù)你們
19、Legend: After a memorable battle with a powerful lich, Arete, a powerful psion, took the time to explore the path of lichdom. ─── 傳說(shuō):在一次值得紀念的,與強大巫妖的戰斗之后,奧雷特,一個(gè)強大的心靈術(shù)士,開(kāi)始去探索巫妖的領(lǐng)域。
20、The innate ability of Lich, Dispell of Lich, will now deal 300 damage to summoned unit instead of 500. ─── 巫妖的天生技能尸巫之散對召喚單位傷害從500調整為300。
21、Abilities: Increase from the base creature as follows: Agy +2, Int +4, Cha +2. As an undead creature, a lich has no Stamina score. ─── 屬性:從基礎生物的屬性上增加:力量+2,智力+4,魅力+2。作為亡靈生物,巫妖沒(méi)有耐力屬性。
22、Power of the North (Su): A lich casts spells with the cold descriptor as a caster 3 levels higher for the purposes of determining damage, DCs, and other variable effects based on caster level. ─── 北地之力(超自然):巫妖施放冰系法術(shù)的時(shí)候,在所造成的傷害,DC,以及所有受施法者等級影響的效果上,視同于比自身高3級的施法者。
23、A lich fighting without weapons uses either its touch attack or its primary natural weapon (if it has any). ─── 不帶武器的巫妖使用接觸攻擊或者主要天生武器(如果他有的話(huà))。
24、Since hunters could not upgrade from the ammo available at the launch of Lich King, their damage had started and would continue to fall behind as other classes upgraded their gear. ─── 在巫妖王之怒上線(xiàn)后,獵人的彈藥傷害輸出一直沒(méi)有升級,他們的攻擊沒(méi)有提高,也漸漸落后于其他的職業(yè)。
25、Wrath of the Lich King builds on the rich foundation established in World of Warcraft and The Burning Crusade, providing a wealth of new content for players to explore. ─── 巫妖王的憤怒是以魔獸世界及其(首部)資料片燃燒的遠征為基礎,為玩家提供了一系列新的內容去探索。
26、68 Highlord Darion Mograine says: So too do the Knights of the Ebon Blade...While our kind has no place in your world, we will fight to bring an end to the Lich King. ─── 大領(lǐng)主達里安.莫格萊尼說(shuō):黑鋒要塞的騎士也一樣...盡管你們的世界不允許我們的存在,我們將為了打倒巫妖王而戰斗到底。
27、A: Yes, we plan to add more bind-to-account items in the future, including the Wrath of the Lich King Collector’s Edition pet and the heirloom items being introduced in Wrath of the Lich King. ─── A:是的。將來(lái)我們計劃增加新的帳號綁定物品,包括巫妖王之怒豪華版本寵物和巫妖王之怒中的金色物品。
28、Illidan's attack shattered the Lich King's defenses and ruptured the very roof of the world. ─── 伊利丹的法術(shù)粉碎了巫妖王的防御力量并割裂了世界之脊。
29、Mrs Lich's family was quickly evacuated from her small hamlet in Hoa An district, along with a dozen other ethnic Tay families. ─── 她回憶說(shuō),有人告訴他們往南邊跑。
30、Illidan's theft sealed the defeat of Archimonde in Azeroth. Still, the victory was of short duration as the Lich King ordered Arthas to return to Northrend. ─── 伊利丹的竊顱行動(dòng)使得阿克蒙德在艾澤拉斯的失敗成為定局。短暫的勝利之后,巫妖王命令阿爾薩斯返回諾森德。
31、Die Triode nennt man auch den Transistor,einschlie ßlich PNP und NPN. ─── 6數據結構是計算機科學(xué)算法理論基礎和軟件設計的基礎。
32、Even if you were to strike down the Lich King, another would have to take its place. ─── 即使你們擊敗了巫妖王也必須要有其他人來(lái)繼承這個(gè)位置。
33、An obsidian construct brought to life accidentally by the Lich King's necromancers, this heartless monstrosity stays animate through devouring magic in the world aroud it. ─── 在偶然地被巫妖王的亡靈法師們賦予了生命后,這具黑曜石雕像便成了一頭依靠吸食四周魔法為生的無(wú)情的怪物。
34、Building on thefoundation established in World of Warcraft, The Burning Crusadeand Wrath of the Lich King, Cataclysm of the Maelstrom will add a richvariety of content to an already massive game. ─── 在魔獸世界,燃燒的遠征和巫妖王之怒的基礎上,大漩渦的災變會(huì )在本已架構龐大的游戲中再加入豐富多元的內容。
35、06 Highlord Darion Mograine yells: The skies turn red with the blood of the fallen! The Lich King watches over us minions! Leave only ashes and misery in your destructive wake! ─── 大領(lǐng)主達里安.莫格萊尼喊道:天空將被墮落之血染紅!巫妖王在看著(zhù)我們這些仆從!在你們的毀滅之路上除了灰燼輿苦難甚麼都不要留下!
36、" Mrs Lich's family escaped to safety.Just 18 days later, in the same Hoa An district, retreating Chinese soldiers reportedly hacked to death 43 people - mostly women and children. ─── 18天后,從同一地區撤退的中國士兵據報砍死了43個(gè)越南人,其中大部分是婦女和兒童。
37、A15. Resolve "destroyed" Effects : Some effects trigger when a creature is destroyed, such as Brain Sucker, Corpse Collecting, Cowardly, and the Lich Necromancer's commander effect. ─── 處理“被消滅時(shí)”效應:某些效應會(huì )在生物被消滅時(shí)觸發(fā),如吸取大腦、尸體收集、膽怯以及死靈法師巫妖的指揮官效應。
38、A story-driven approach is a key element to the designs of all the new dungeons in Wrath of the Lich King. ─── “故事導向”的途徑是《巫妖王之怒》中地下城設計的最主要元素。
39、For without the control of the Lich King, the scourge would wash over the world like locusts, destroying all that they touched. ─── 沒(méi)有了巫妖王的控制,天災將像蝗蟲(chóng)一樣橫掃這個(gè)世界,殺死他們遇上的一切。
40、Insider: What sort of challenges are there in this artistic transition from The Burning Crusade to Wrath of the Lich King? ─── 那么,從燃燒遠征到巫妖王之怒的藝術(shù)風(fēng)格過(guò)渡里,將有些什么樣的挑戰呢?。
41、An obsidian construct brought to life accidentally by the Lich King's necromancers, this heartless monstrosity stays animate through devouring magic in the world aroud it. ─── 在偶然地被巫妖王的亡靈法師們賦予了生命后,這具黑曜石雕像便成了一頭依靠吸食周?chē)Х樯臒o(wú)情的怪物。
42、One exciting new feature in Wrath of the Lich King is that all raid content will be available in both 10- and 25-person versions with completely independent progressions paths. ─── 巫妖王之怒一個(gè)令人興奮的新特征就是所有的副本內容將以完全獨立的處理方式對10人和25人版本都適用。
43、Lich masters have the ability to deal damage to all creatures (excluding mechanisms and undead) in the surrounding area (radius 3 tiles). ─── 巫大師能夠對周?chē)模?×3)所有兵種(包括機器和不死)造成傷害。
44、Years after the destruction of Draenor, the immensely powerful Lich King created a new breed of death knights: malevolent, rune-wielding warriors of the Scourge. ─── 很多年后,無(wú)比強大的巫妖王制造了新一代死亡騎士:那些燃燒軍團中險惡的,揮舞著(zhù)符文的戰士。
45、It sounded like the impossible voice of a shriveled dead thing, a mummy or a lich that, by rights, should have no voice at all. ─── 它聽(tīng)起來(lái)就像是枯萎的已死物體,比如木乃伊或者巫妖的聲音,但事實(shí)上,它們是不可能有聲音的。
46、I knew nothing of this lich of yours, but when my diviners told me of the explosion, I feared for the integrity of the Snarl's prison. ─── 我對你們那位巫妖一無(wú)所知,但當我的占卜師告訴我爆炸發(fā)生時(shí),我開(kāi)始擔心死結囚牢的完整性。
47、In upcoming Patch 1.11, one of Azeroth's most feared denizens - Kel'Thuzad, the right hand of the Lich King himself - will return with the horrors of the undead in his wake. ─── 在即將到來(lái)的1.11補丁中,令艾澤拉斯居民們發(fā)抖的一個(gè)人--克爾蘇加德,巫妖王的右手即將來(lái)散播不死族的恐懼。新的副本-克爾蘇加德的老家,納斯克馬斯即將開(kāi)放。
48、Kel'Thuzad is known for betraying the Kirin Tor of Dalaran by serving the Lich King as a necromancer, and later as a lich risen by King Arthas at the Sunwell. ─── 克總回北地,地球人都知道,達拉然法師議會(huì )肯瑞托的叛徒,巫妖王的仆人,被阿爾薩斯用太陽(yáng)井復活的巫妖。
49、Tuz Kuz is a powerful lich adept at controlling insect minions. ─── 塔茲克茲是名擅長(cháng)于操縱昆蟲(chóng)仆役的的巫妖。
50、lich gate ─── 停柩門(mén), ph. 停柩門(mén)
51、You must destroy the Lich King! ─── 你必須摧毀巫妖王!
52、As part of Lich's Mirror's effect, it typically shuffles itself into your library. ─── 巫妖秘鏡之效應中的一部分,通常會(huì )讓你將它本身洗入你的牌庫。
53、Brave the harsh new continent of Northrend, the icy domain of the Lich King. ─── 開(kāi)辟新的區域:諾森德大陸,巫妖王的領(lǐng)地。
54、Any abilities that trigger when the permanents leave play will be put on the stack after Lich's Mirror's entire effect has been applied. ─── 任何因永久物離場(chǎng)而觸發(fā)的異能,會(huì )在巫妖秘鏡的整個(gè)效應全部生效之后才進(jìn)入堆疊。
55、The Lich King: It is I, the Lich King. Danger draws near the Frozen Throne!You must return to Northrend immediately! Obey! ─── 巫妖王:是我--巫妖王.危險已經(jīng)降臨了冰封王座!你必須立刻回到諾森德大陸!快服從我的命令!
56、The Lich King yells: When next we meet, it won't be on holy ground, paladin. ─── 下次見(jiàn)面的時(shí)候,就不會(huì )在有圣光護佑你們的地方了,圣騎士.
57、Mind Blast (Su): At will, as a standard action, the Lich King can unleash a massive psionic attack in a cone 60 feet long. ─── 心靈沖擊:任意一個(gè)標準動(dòng)作下,荔枝王都可以釋放對面前60英尺的錐型范圍釋放群體超能力攻擊。
58、Highlord Trion Fordring says: I make a promise to you now,brothers and sisters;The Lich King will be defeated!On this day,I call for a union. ─── 大領(lǐng)主提里奧.弗?。何蚁蚰銈兯腥嗽S諾,兄弟姐妹們。巫妖王終將將被擊??!在今天,我倡議我們團結起來(lái)!
59、Lich's Mirror has no effect if you concede the game. If you concede, you'll lose. ─── 如果你認輸,巫妖秘鏡并不會(huì )生效。如果你認輸,就是輸了。
60、We do have ideas to improve how the 10 person and 25 person dungeons coincide in Wrath of the Lich King, but nothing concrete we can discuss at this point. ─── 當然,當這兩種游戲方式產(chǎn)生沖突時(shí),我們也有應對之法;只是目前我不能透露進(jìn)一步的信息而已。
61、Left to rule his kingdom unopposed, the Lich King began preparing for his true mission in the world. ─── 在一統諾森德大陸之后,巫妖王準備著(zhù)手執行他真正的任務(wù)。
62、Einen Tag sp?ter sollten sich die Probanden schlie?lich zwischen jeweils zweider 80 Reiseziele entscheiden, die sie zu Beginn der Versuche gleich bewertethatten. ─── 一天后,被試應最終對剛開(kāi)始做過(guò)評價(jià)的80個(gè)旅游目的地彼此之間分別選出兩個(gè)。
63、Before bringing the battle to the Lich King, both the Horde and Alliance must overcome the immediate threat of the vrykul and answer the questions that the warriors' reemergence has posed. ─── 在與巫妖王交戰之前,部落和聯(lián)盟都必須克服瑞庫爾的威脅并解答這群戰士覺(jué)醒的疑問(wèn)。
64、Week of Lich: Double growth for Liches and Archliches. ─── 巫妖周:巫妖產(chǎn)量加倍。
65、Eventually he became one of the Lich King's most valuable servants. ─── 最終,他成為了巫妖王手下最有價(jià)值的仆人之一。
66、Orc Unit: Convert its life * Lich's STR/3 to Lich's life. ─── 獸族單位:將目標單位生命值的(巫妖力量/3)%轉換為巫妖的生命值。
67、Ihr Reichtum an fast jeder Mensch auf der Erde, einschließlich der jetzt, wie auch die Geschichte des Lebens aller Personen. ─── 你的財富幾乎是每一個(gè)地球人,包括現在以及歷史上的所有人的生命的一部分。
68、Great Lich Hefas resurrected the warrior and employed him. ─── 后來(lái)大尸巫復活并雇傭了這位戰士。
69、The Lich King has given me true power. ─── 巫妖王給我的才是真正的力量。
70、However, Illidan's forces return from Outland and position themselves around the Lich King's tower before Arthas can reach it. ─── 但是,伊利丹的軍隊從外域歸來(lái),在阿爾薩斯到達巫妖王之塔之前將其包圍。
71、Kil'jaeden captures the fleeing Ner'zhul and irreversibly transforms him into the Lich King, encasing him in a block of ice. ─── 基爾加丹抓住了逃逸的耐奧祖并以不可逆轉的形式將之變?yōu)槲籽?將他罩在了一塊冰殼中。
72、Human Unit: Convert its life * Lich's STR/4 to Lich's life.Other Summoned Unit: Convert its life * Lich's INT/5 to Lich's mana and its life * Lich's STR/5 to Lich's life. ─── 其他召喚類(lèi)單位:將目標單位生命值的(巫妖力量/5)%轉換為巫妖的生命值,并同時(shí)將其生命值的(巫妖智力/5)%轉換為巫妖的魔法值。
73、Wrath of the Lich King will introduce a vast new land and many new dungeons to the game. ─── 巫妖王之怒將介紹大量的新地區和新地下城到游戲中。
74、Mitte April). Sie m黡sen pers鰊lich an der Universit鋞 einschreiben. ─── 意思應該就是應該4月中旬前注冊也是有效的吧。
75、The Lich King yells: You could have been my greated champion, Fordring: A force of darkness that would wash over this world and deliver it into a new age of strife. ─── 巫妖王大喊:你可能會(huì )是我最強的勇士,弗?。阂粋€(gè)從黑暗來(lái)的力量可能洗劫這個(gè)世界,并且讓它成為一個(gè)新的時(shí)代。
76、So sweet was his tooth that he would tiptoe up to pine trees And lich their resin, hopping it would taste as treacly as it looked. ─── 他是如此貪戀甜食,甚至會(huì )偷偷摸摸地爬上松樹(shù),舔口松脂,嘗嘗它是不是像看起來(lái)那樣甜。
77、However Hoang Van Lich now never has to worry about the weather. ─── 現在,Hoang Van Lich再也不用為天氣發(fā)愁了。
78、Highlord Tirion Fordring says: The Lich King must answer for what he has done and must not be allowed to cause further destruction to our world. ─── 巫妖王必須為其罪行付出代價(jià),使其不再能夠對我們的世界進(jìn)行更多的毀滅。
79、For example, if your life total is -4 when you would lose the game, Lich's Mirror's effect will cause you to gain 24 life. ─── 舉例來(lái)說(shuō),如果你原本將輸掉時(shí)的總生命是-4,則巫妖秘鏡會(huì )讓你獲得24點(diǎn)生命。
80、The character in the middle of the picture is the Lich King's mightiest Death Knight and also the legion commander. ─── 位于畫(huà)面中央的是尸巫王手下最強大的死亡騎士也是軍團指揮。
81、The Lich King watches over us minions! ─── 巫妖王在看著(zhù)我們這些仆從!
82、Sacrificing his allies for magical power, the Lich is a murderer without a trace of warmth. ─── 他可以為了恢復魔力而不惜犧牲自己的盟友,是個(gè)不折不扣的冷血殺手。
83、World of Warcraft:Wrath of the Lich King will add a new option to the game's class roster with the introduction of the first hero class, the necromantic death knight. ─── 在即將到來(lái)的最新資料片WOW:WTK中將加入一個(gè)新的英雄職業(yè),也就是使用邪惡魔法的死亡騎士。
84、Kil’jaeden, one of the lords of the Burning Legion, first created the Lich King to wreak havoc and terror across Azeroth. ─── 基爾加丹,燃燒軍團的一位首領(lǐng),最先創(chuàng )造了巫妖王到艾澤拉斯去制造破壞和恐慌。
85、Kel'Thuzad looked upon the Lich King's growing army and named it the Scourge, for soon it would march upon the gates of Lordaeron and scour humanity from the face of the world. ─── 克爾蘇加德管理著(zhù)這支日益龐大的部隊,并稱(chēng)他們?yōu)?天災",不久之后,它就會(huì )踏進(jìn)洛丹倫的大門(mén),并把人類(lèi)從這個(gè)世界上永遠抹掉。
86、Even if you were to strike down the Lich King another would have to take his place. ─── 即使你終結了巫妖王,也會(huì )有其他人繼承這個(gè)位置的。
87、A powerful lich has unleashed an undead horde against a dwarf city. ─── 一個(gè)強大的巫妖釋放了一個(gè)不死部落以對抗一座矮人城市。
88、Kil'jaeden captures the fleeing Ner'zhul and irreversibly transforms him into the Lich King, encasing him in a block of ice. ─── 基爾加丹抓住了逃逸的耐奧祖并以不可逆轉的形式將之變?yōu)槲籽?,將他罩在了一塊冰殼中。
89、When Ner'zhul the Lich King took control of Northrend, he used his powerful magics to raise the ancient Dragon skeletons from the dead. ─── 當巫妖王耐奧祖控制了諾森德大陸后,他使用強大的魔法復活了死去巨龍的尸骨。
基因檢測對于預防腫瘤和腫瘤治療有什么幫助?
基因檢測是目前國際提倡精準治療的重要組成部分,是大數據時(shí)代醫學(xué)科學(xué)進(jìn)步的重要體現。目前在腫瘤界,無(wú)論國內還是國外,要求每個(gè)患者均應該給予基因檢測,看有無(wú)合適的靶點(diǎn),使每個(gè)腫瘤患者不要錯過(guò)靶向藥物治療的機會(huì )。這對于延長(cháng)患者生命、提高生存質(zhì)量有著(zhù)不可忽視的作用。
宣傳、科普基因檢測是每一個(gè)腫瘤醫務(wù)工作者的責任和義務(wù),呼吁廣大患者朋友能對基因檢測和靶向治療有更多的認知,給患者多一條出路。
基因檢測對于預防腫瘤和腫瘤治療有什么幫助?
基因檢測可以用于預測癌癥風(fēng)險,還可以用于協(xié)助治療,提示哪種治療方式更加有效。簡(jiǎn)而言之,基因檢測對于預防、治療腫瘤和癌癥均有較大作用。
先來(lái)說(shuō)說(shuō)基因檢測是啥?
生命的起始階段,每個(gè)人的老爸出個(gè)精子,老媽出個(gè)卵子,然后兩者結合,形成受精卵。受精卵是一個(gè)細胞,就像是一個(gè)微小的雞蛋,它的“蛋黃”里保存著(zhù)老爸和老媽給的“信息”,它們決定你以后是長(cháng)成男人還是女人,黑人、白人或是黃種人,長(cháng)得像鹿晗還是張曼玉,這些“信息”就是基因,然后受精卵開(kāi)始分裂,一個(gè)變兩個(gè),兩個(gè)變四個(gè),數量不斷增多,細胞們各司其職,讓你發(fā)育成現在的樣子,可以愛(ài),可以恨,可以思考人生,還可以在屏幕前看這篇科普?;驒z測,就是通過(guò)測序的辦法發(fā)現這些“信息”的內容。
目前疾病的檢查分 5 個(gè)等級:組織器官水平、臨床前、細胞水平、蛋白質(zhì)水平、基因分子水平 ,而基因檢測是最早的預警。
基因檢測對于預防和治療的價(jià)值,有一個(gè)非常典型的例子,就是BRCA2突變。該基因原本是抑癌基因,顧名思義,就是抑制癌癥產(chǎn)生和發(fā)展的基因,發(fā)生突變后,可以增加乳腺癌、卵巢癌、胰腺癌和前列腺癌的發(fā)病風(fēng)險。根據2013年發(fā)布在《臨床醫生腫瘤雜志》(《A cancer journal for clinicians》,簡(jiǎn)稱(chēng)《CA》)上的數據(原文標題《Recent Progress in Pancreatic Cancer 》),幾乎4%-10%的德系猶太人(Ashkenazi Jews)胰腺癌患者攜帶家族性BRCA2突變,而且這種突變的比例隨著(zhù)親戚中胰腺癌患者的數量呈正比,如果有不小于2個(gè)親戚也得了胰腺癌,那么德系猶太人胰腺癌患者的BRCA2突變比例是6%~12%,如果有不小于3個(gè)親戚得了胰腺癌,則德系猶太人胰腺癌患者的BRCA2突變比例是16%。
雖然目前臨床醫生不推薦基因檢測作為常規篩查手段,但對于如上述的高危人群,基因檢測不失為一種早期篩查的好方法。
幾年前的爆炸性新聞,好萊塢女星安吉麗娜朱莉,也是因為發(fā)現BRCA突變,乳腺癌的風(fēng)險遠遠超過(guò)常人,所以選擇預防性地切除乳房。
基因檢測不單單可以預測某些癌癥發(fā)生的風(fēng)險,還可以預測哪些治療更有效。研究發(fā)現,對于BRCA2突變的患者,使用烷化劑(如卡鉑)的治療效果比沒(méi)有BRCA2突變的相同癌癥、相同病情的患者好。
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