?heterozygosity

heterozygosity發(fā)音

英：[het?r??za?'g?s?t?]　　美：[het?ro?za?'g?s?t?]

英：　　美：

heterozygosity中文意思翻譯

[生]雜合性, 異型結合性

heterozygosity同義詞

heterozygosity反義詞

homozygosity

heterozygosity常見(jiàn)例句

1 、In cases where prednisolone acetate was administered, we found a significant correlation between N363S heterozygosity and steroid-induced ocular hypertension.───在潑尼松龍組,N363S雜合性與類(lèi)固醇誘導的眼內高壓顯著(zhù)相關(guān)。

2 、Using genetic parameters to determine the heterozygosity and the mean FST value of each population, we inferred the evolutionary history of Castanopsis carlesii in Taiwan.───同功酵素的電泳分析主要用來(lái)探討長(cháng)尾栲的族群遺傳變異，共選擇22個(gè)族群。

3 、loss of heterozygosity(LOH)───雜合性丟失

4 、The genetic differentiation mechanism of populations and the cause of indistinctively heterozygosity deficiency were discussed.───初步討論了雜合子缺失不顯著(zhù)原因和群體間可能遺傳分化機制。

5 、Loss of heterozygosity at MCC, DCC and YNZ22 loci containing VNTR segment in colorectal carcinoma───大腸癌MCC、DCC基因和YNZ22位點(diǎn)串聯(lián)重復序列的雜合性丟失現象

6 、(2) polymorphous blood albumen existed in 6 loci and the average loci heterozygosity was 0.2584;───(2)血液蛋白在6個(gè)基因座上具有多態(tài)性，平均基因座雜合度為0.2584；

7 、Ubiquitin associated protein 1(UBAP1) is a novel member of UBA domain protein family, located at human chromosome 9p21 22 where loss of heterozygosity frequently occurs in nasopharyngeal carcinoma.───UBAP1(ubiquitinassociatedprotein 1)基因是最近克隆的一個(gè)**于人類(lèi)染色體 9p2 1 2 2鼻咽癌雜合性丟失高頻區的泛肽相關(guān)蛋白家族新成員 .

8 、Heterozygosity is sustained by two methods.───異質(zhì)型可以由二種方式來(lái)證明。

9 、Microsatellite analysis showed that both loss of heterozygosity and microsatellite instability of FHIT gene existed in laryngeal carcinoma and the former was more common.───微衛星多態(tài)分析表明，FHIT基因在喉癌中既存在雜合性丟失，又存在微衛星不穩定現象，但以前者為主。

10 、Keywords Laryngeal neoplasms;Squamous cell carcinoma;Genes;Loss of heterozygosity （LOH）;DNA;Satellite;Microsatellite;───喉腫瘤;鱗狀細胞癌;基因;雜合性缺失;DNA;衛星;微衛星;

11 、complex heterozygosity───復合異質(zhì)結合性

12 、expected heterozygosity───期望雜合性

13 、He, Expected heterozygosity; PIC, Polymorphic information content; E, Mean number of effective alleles. Population codes see Table 1.───期望雜合度;PIC:多態(tài)信息含量;E:平均有效等位基因數。群體代碼同表1

14 、loss of heterozygosity───雜合子丟失

15 、Keywords Breast cancer;Loss of heterozygosity;Chromosoma;───乳腺癌;雜合性缺失;染色體;

16 、Will it be sufficient to rely on the heterozygosity of one clone?───是否依靠一個(gè)無(wú)性系的雜合性就足夠了?

17 、The proportion of polymorphic loci and the mean average heterozygosity of the population were 24%and 0.086,respectively.───從實(shí)驗可見(jiàn)淮河鯉的同工酶系統具有明顯的多態(tài)性，多態(tài)座位比例為24%，平均雜合度為0.086。

18 、phage heterozygosity───噬菌體雜合性

19 、The average number of alleles detected by a pair of primer was 6.83. The average PIC was 0.805. And the population heterozygosity was 0.833.(3) We found there were significant correlations among 13 markers and 13 characters through GLM.───平均檢測到6.83個(gè)等位基因(5-8個(gè))，平均雜合度和多態(tài)信息含量分別為0.833和0.805。 (3)通過(guò)GLM分析，篩選出13個(gè)多態(tài)性位點(diǎn)與所選用的絲羽烏骨雞的13個(gè)屠宰性狀存在顯著(zhù)相關(guān)。

20 、heterozygosity advantage───雜合優(yōu)勢

21 、Methods The loss of heterozygosity (LOH)of YNZ22, APC, MCC and DCC genes was examined by PCR RFLP technique in 60 IM cases.───方法 應用PCR?RFLP法檢測了60 例腸化生組織中YNZ22、APC 、MCC、DCC基因雜合性缺失現象。

22 、METHODS: Twenty-three fresh resection samples of colorectal carcinomas were studied by the polymerase chain reaction (PCR) to detect the loss of heterozygosity of DCC.───方法:采用聚合酶鏈反應方法(polymerasechainreaction,PCR)對23例結直腸癌組織新鮮標本DCC基因雜合性缺失(lossofheterozygosity,LOH)進(jìn)行研究。

23 、According to the allele frequencies of 31 microsatellite sites,mean heterozygosity(H),polymorphism information content(PIC) and genetic distances(DA) were calculated for each breed.───利用等位基因頻率計算各群體的平均遺傳雜合度(H)、多態(tài)信息含量(PIC)和群體間的遺傳距離(DA),分析其遺傳多樣性。

24 、Keywords Colorectal carcinoma;Microsatellite instability;Loss of heterozygosity;Polymerase chain reaction（PCR）;Tumor suppressor gene;───關(guān)鍵詞結直腸癌;微衛星不穩定性;雜合性缺失;聚合酶鏈反應;抑癌基因;

25 、Keywords Laryngeal neoplasms;Carcinoma;squamous cell;Loss of heterozygosity;───喉腫瘤;癌;鱗狀細胞;雜合子丟失;

26 、Results obtained with both types of DNA markers showed lack of major differences between the genetic structure of the two stocks: heterozygosity values and allele frequencies were very similar.───兩類(lèi)DNA標記物獲得結果表明，這兩群親魚(yú)遺傳結構之間沒(méi)有大的差異：雜合度值和等位基因頻率都非常相似。

27 、Heterozygosity loss at the APC/MCC locus in colorectal cancer───大腸癌組織APC/MCC基因雜合的缺失

28 、Loss of heterozygosity on the genetic loci of the short arm of chromosome 1 in sporadic colorectal carcinoma───散發(fā)性結直腸癌1號染色體短臂遺傳位點(diǎn)雜合缺失

29 、Study of loss of heterozygosity (LOH) on multiple chromosome arms in hepatocellular carcinomas───原發(fā)性肝細胞癌多染色體雜合性丟失研究

30 、Frequent Loss of Heterozygosity Associated with bcr-abl Gene in Chronic Myeloid Leukemia───慢性粒細胞白血病bcr-abl基因相關(guān)的頻繁雜合性丟失(英文)

31 、The average heterozygosity of offspring and polymorphic information content(PIC)etc were lower than those of their parents.───子代的平均期望雜合度(He)、平均觀(guān)測雜合度(Ho)和平均多態(tài)性信息含量(PIC)等指標均低于親代。

32 、Detection of Loss of Heterozygosity at Chromosome 5q21-q22 in Colorectal Carcinomas Using Microsatellite Marker───應用微衛星多態(tài)標記進(jìn)行大腸癌中5q21-q22雜合性丟失的初步研究

33 、enforced heterozygosity───強制雜合性

34 、Keywords leukoplakia;erythroplakia;squamous cell carcinoma;loss of heterozygosity;microsatellite instability;denaturing high performance liquid chromatography;───關(guān)鍵詞白斑;紅斑;鱗狀細胞癌;雜合性缺失;微衛星不穩定;變性高效液相色譜分析;

35 、Assaying Loss of Heterozygosity Involving the APC Gene in Patients with Myeloid Leukemias by PCR-RFLP Analysis───以PCR-RFLP分析檢測髓系白血病人APC基因的雜合性缺失

36 、Keywords ovarian cancer;DNA hypermethylation;tumour suppressor gene;loss of heterozygosity;───卵巢癌;腫瘤抑制基因;DNA甲基化;雜合性丟失;

37 、Keywords Oligodendroglioma;Loss of heterozygosity;Polymerase chain reaction;───少突神經(jīng)膠質(zhì)瘤;雜合子丟失;聚合酶鏈反應;

38 、A preliminary study of loss of heterozygosity on chromosome 1p in primary hepatocellular carcinoma───原發(fā)性肝細胞癌1號染色體雜合子丟失的初步研究

39 、Correlation between Expressions of DCC, P53 and VEGF Genes in Colorectal Carcinoma and the Clinic Signification of the DCC Gene with the Loss of Heterozygosity───DCC與P53、VEGF基因在結直腸癌表達的相關(guān)性研究及DCC基因雜合性缺失的臨床意義

40 、15 Fang DC, Jass JR, Wang DX. Loss of heterozygosity and loss of expression of the DCC gene in gastric cancer. J Clin───14王東旭,房殿春,劉為紋,羅元輝,魯榮.胃黏膜腸化生組織中多種抑癌基因的雜合缺失.中華病理學(xué)雜志1999;28:264-267

41 、Loss of heterozygosity at different chromosomes in pa-tients with breast cancer.───乳腺癌病人不同染色體位點(diǎn)上雜合缺失的研究

42 、Keywords Carcinoma;hepatocellular;DNA;Stallite;Trinucleotide repeat expansion;Loss of heterozygosity;───關(guān)鍵詞癌;肝細胞;DNA;衛星;三核苷酸重復擴增;雜合子丟失;

43 、Keywords microsatellite locus;polymerase chain reaction;heterozygosity;polymorphism information content;───關(guān)鍵詞微衛星位點(diǎn);聚合酶鏈反應;雜合度;多態(tài)信息量;

44 、The polymorphism and polytypism of male cones are based upon the rich genetic diversity and high heterozygosity among individuals and populations of P. yunnanensis.───云南松居群具有較高的遺傳多樣性和雜合度是其雄球花多態(tài)性和多型性豐富的遺傳基礎。

45 、The mean heterozygosity of the Yangzhou goose was 0.7568, and was the highest in 5 goose breeds.───其中，揚州鵝平均基因雜合度最高，為0.7568，遺傳多樣性最豐富；

46 、It was found that loss of heterozygosity(LOH) at MCC,LOH of DCC and LOH of YNZ22 loci were detected in 34.8%,36.0%and 43.3% of informative cases,respectively.───大腸癌MCC基因LOH率為34.8%； DCC基因為36.0%，YNZ22位點(diǎn)為43.3%；

47 、Results showed that the number of alleles for the 10 microsatellite loci, heterozygosity and PIC (polymorphism information content) in the Dorset population were 8?16, 0.8370?0.9252, and 0.8221?0.9167, respectively.───Dorset群體中,等位基因個(gè)數為8~16個(gè),雜合度為0.8370~0.9252,多態(tài)信息含量為0.8221~0.9167;

48 、Method Polymerase chain reaction and restriction fragment length polymorphism were used to examine 40 oral malignant tumors for loss of heterozygosity at chromosome **.───方法應用聚合酶鏈反應限制性片段長(cháng)度多態(tài)性分析方法對40例口腔鱗癌組織中3號染色體的等位基因雜合缺失進(jìn)行測定。

49 、A specific set of five loci linked to an increased loss of heterozygosity and allelic imbalance in the stroma of sporadic tumors was associated with nodal metastases in the absence of TP53 mutations.───一套特定的5個(gè)位點(diǎn)的聯(lián)系，以提高雜合性缺失和等位基因失衡的基質(zhì)零星的腫瘤與淋巴結轉移的，在沒(méi)有tp53突變。

50 、Transitional cell carcinoma of urinary bladder related loss of heterozygosity of microsatellite loci on chromosomes 9 and 17 in Chinese───國人9號和17號染色體膀胱移行細胞癌相關(guān)微衛星位點(diǎn)的雜合性丟失

51 、Keywords loss of heterozygosity;microsatellite;refined deletion mapping;chromosome;colorectal cancer;hereditary distance;───關(guān)鍵詞染色體;雜合缺失;微衛星;結直腸癌;精細**;遺傳距離;

52 、The mean effective number of alleles per locus (Ae) is 1.227 0; the mean expected heterozygosity per locus (He) is 0.117 0;───三疣梭子蟹的平均每個(gè)位點(diǎn)的等位基因的有效數目Ae為1.2270,平均每個(gè)位點(diǎn)的預期雜合度He為0.1170,實(shí)際雜合度Ho為0.2159。

53 、According to the allele frequencies of 31 microsatellite sites, mean heterozygosity (H), polymorphism information content (PIC) and D(subscript A) genetic distances were calculated for each breed.───利用等位基因頻率計算出各群體的平均遺傳雜合度(H)、多態(tài)信息含量(PIC)勻和群體間的D(下標A)遺傳距離。

54 、Clinical factors and loss of heterozygosity of APC suppressor gene in oral squamous cell carcinoma───口腔鱗癌臨床因素與APC基因雜合缺失的研究

55 、THE COMPARISON STUDY ON HETEROZYGOSITY IN FOUR SPECIES OF SHRIMPS───幾種優(yōu)良養殖對蝦雜合性的比較研究

56 、Keywords MDS;microsatellite instability;loss of heterozygosity;───微衛星遺傳不穩定性;遺傳性缺失;

57 、Thirteen (2/15) percent of acute leukemia patients had loss of heterozygosity (LOH);the rate was higher than that in other leukemia types.───15例急性白血病中2例有LOH，比其他白血病發(fā)生率高。

58 、Keywords oral leukoplakia;oral squamous cell carcinoma;microsatellite instability;loss of heterozygosity;───口腔白斑;口腔鱗癌;微衛星不穩定;雜合性缺失;

59 、Keywords FHIT gene Oseteosarcoma Loss of heterozygosity Microsatellite in sta bility;───FHIT基因;骨肉瘤;雜合性丟失;微衛星序列不穩定性;

60 、The mean heterozygosity value of BBP is 0.099 9,and that of DBP is 0.124 3;───2種群之間的遺傳距離為 0 .0 15 9。

61 、Frequency of compound heterozygosity was similar in both groups.───兩組的對偶基因為異型合子的發(fā)生頻率則相似。

62 、inversion heterozygosity───異質(zhì)倒位接合性

63 、The test shows an absence of heterozygosity.─── 檢測結果顯示DNA缺少雜合性

64 、Keywords Colorectal carcinoma Microsatellite instability Loss of heterozygosity Tumor suppressor gene Polymerase chain reaction;───大腸癌;微衛星不穩定性;雜合性缺失;抑癌基因;聚合酶鏈反應;

65 、Keywords Chinese native chicken breed;microsatellite;heterozygosity;fuzzy cluster analysis;───關(guān)鍵詞地方雞種;微衛星;雜合度;模糊聚類(lèi);

66 、The average heterozygosity and effective number of alleles among 15 populations were 0.2746 and 1.559 respectively.───15個(gè)群體結構基因座平均雜合度和有效等位基因數分別為0.2746和1.559；

67 、Associations between compartment-specific TP53 status, loss of heterozygosity or allelic imbalance, and clinical and pathological characteristics were computed.───協(xié)會(huì )之間的隔間具體tp53地位，雜合性缺失或等位基因不平衡現象更加嚴重，臨床及病理特征的計算機。

68 、The RAPD and SSR molecular marker polymorphism loci and their ratio,genetic dispersion and heterozygosity,genotype number in 7 populations and intrapopulation gene differentiation were analyzed.───對7個(gè)陸地棉分子標記輔助輪回選擇聚合育種和表型選擇群體內的RAPD和SSR分子標記多態(tài)位點(diǎn)數及其比例,遺傳離散度與雜合度,基因型種類(lèi)數,不同群體間的遺傳分化等進(jìn)行研究。

69 、Study on loss of heterozygosity of DCC in primary gastric carcinoma.───原發(fā)性胃癌中DCC抑癌基因雜合性丟失的研究

70 、Those who had low heterozygosity (such as TPOX) changed obviously with the quantity of samples, while those had high heterozygosity (such as FGA) changed a little with the quantity of samples.───雜合度較低的位點(diǎn)隨樣本量的變化波動(dòng)較大, 雜合度較高的位點(diǎn)隨樣本量的變化波動(dòng)較小。

71 、Keywords Laryngeal neoplasms;Carcinoma;squamous cell;Precancerous conditions;Microsatellite DNA;Loss of heterozygosity;───喉腫瘤;癌;鱗狀細胞;癌前病變;微衛星DNA;雜合性缺失;

72 、The result showed the average heterozygosity (H) of these eight blood protein (enzyme) sites in Mongolian horse, Sanhe horse and Thoroughbred horse were 0.3782, 0.3956, 0.2571, respectively.───平均雜合度分別為：蒙古馬0.3782，三河馬0.3956和純血馬0.2571。聚類(lèi)分析表明，蒙古馬與三河馬間的親緣關(guān)系最近，與純血馬的親緣關(guān)系相對較遠。

73 、Keywords individual gene heterozygosity;average daily gain;liveweight;heterosis;swine;───關(guān)鍵詞個(gè)體基因雜合度;日增重;活重;雜種優(yōu)勢;豬;

74 、Cong WM,Wu MC.Features of microsatellite instability and loss of heterozygosity of intrahepatic cholangiocarcinoma[J].Zhonghua Zhongliu Zazhi(Chin J Oncol),2002,24(2):141.───[24]叢文銘,吳孟超.肝內膽管癌的微衛星不穩定性和雜合性缺失特點(diǎn)[J].中華腫瘤雜志,2002,24(2):141.

75 、Gene heterozygosity───基因雜合度

76 、Keywords loss of heterozygosity（LOH） glioblastoma tumor suppressor genes;───關(guān)鍵詞雜合性缺失;膠質(zhì)母細胞瘤;腫瘤抑制基因;

77 、the average observed heterozygosity was 0.6067 and 0.5667;───平均觀(guān)察雜合度為0.6067、0.5667；

78 、When tested for signs of bottlenecks, neither of the two broodstocks displayed significant heterozygosity excess ( P>0.05) under either the SMM or the TPM models (Table 2).───當測試瓶頸現象時(shí)，在SMM或TPM模式下2個(gè)養殖群體沒(méi)有一個(gè)顯示出明顯的雜合度冗余現象(P>0.05)(表2)。

79 、Expression and losa of heterozygosity of DCC gene inhuman lung cancer───抑癌基因DCC在肺癌中的表達及雜合性丟失

80 、Influence of heterozygosity for Parkin mutation on onset age in familial parkinson disease: The genePD study───Parkin基因突變雜合對家族性帕金森病發(fā)病年齡的影響:PD基因研究

81 、Keywords hyperplastic lesions;lung;fragile histidine triad gene;loss of heterozygosity;microsatellite instability;───增生病變;肺;脆性組氨酸三聯(lián)體;雜合性丟失;微衛星不穩定;

為什么說(shuō)基因突變的結果是產(chǎn)生等位基因

基因突變一般是指在基因尺度上的DNA序列的變化，用來(lái)區分染色體突變。

一般基因突變會(huì )包括少數堿基對的突變，或者一段或幾段序列的**入或者刪除，而這些突變之后，原有基因的絕大部分序列并沒(méi)有變化，因此原先在一對染色體上的配對基因仍然能夠配對和同源重組。

我們一般上把能否發(fā)生同源重組，即在染色體水平上，兩個(gè)基因所在的染色體區域能否配對作為是否是等位基因的標準。因此基因突變以后，產(chǎn)生了新的基因，該基因與原基因所在的相對另一條染色體上的基因仍能配對，互稱(chēng)等位基因。

為什么說(shuō)基因突變的結果是產(chǎn)生等位基因

本來(lái)兩條染色體上面是同一個(gè)基因

現在有一條染色體上的一個(gè)基因變了，但是這兩個(gè)基因還是控制同一個(gè)東西的（比如控制單眼皮和雙眼皮）

只是表現性狀不一樣了

這兩個(gè)基因本來(lái)就是同源的

現在雖然表現不一樣了，但是說(shuō)白了還是同一種基因，就是等位基因